I had the same problem with my Samsung TV after recent snow storms caused several power outages and caused the Home button to quit working. The Samsung techs can remotely connect to your TV and do a factory reset. They will instruct you to provide a 8 digit PIN by, yes, holding the Home button for 30 seconds. Obviously, your TV needs to be connected to the Internet OK. After the factory reset you have to go throught the setup again but at least the Home button works again. Here is their support URL"
Can you power cycle the television by unplugging it from the wall outlet for 1-2 minutes and while it is unplugged, remove the batteries from the remote then press the power button to discharge. Plug back in and power up to test.
The TV is connected to the internet. I can reach Prime Video with the voice command and that's fine. I'll replace the remote batteries, but all the other functions on the remote works.