Try this methods to Fix Samsung Galaxy S22 Ultra S Pen Not Working
If it’s a minor bug, then with a simple restart S Pen will start working again. Once the phone reboots fully, S Pen will reconnect.
Press and hold Power Off button and choose Restart. Confirm Restart.
Remove Case or any other Accessories
Fortunately, or sadly, we have a plethora of alternatives when it comes to Screen Protectors, Cases, and other accessories. Not all of them guarantee full compatibility with the Samsung S22 Ultra, and if you’ve chosen such a case, screen protector, or other accessories, it may create such problems. Magnetic closures and clasps may interfere with the S Pen and prevent it from responding. The same goes with screen protectors; try removing the case and then giving it a shot. If it doesn’t work, you could want to remove the screen protector as well.
Change S Pen Tip
S Pen Tip requires replacement over time, however if your S Pen is brand new and you’re confident that no harm has been done to the S Pen, you shouldn’t be concerned if you still need to replace the S Pen Tip. You should have gotten a S Pen replacement tip in the box; use it to replace it.
With the help of changing tool, remove the old S Pen tip.
And then gently push the new S Pen tip by hand only, you’ll hear a slight click sound when tip is inserted correctly.
Use S Pen with Alternate Device
Do you own another Samsung Note or S Series device? Then you may try S Pen with different devices, and if it works flawlessly, there is no problem with S Pen. All Galaxy Note phones are compatible with the S Pen, but only the Samsung Galaxy S21 Series is compatible with the S Pen when it comes to the Samsung Galaxy S Series.
If your S Pen does not function with other compatible devices, you can get it replaced or repaired.
Check for Updates
Navigate to the Settings > Software Update and then Check for Updates. Download and install if there’s any update available. This will eradicate all the possibilities of errors and issues that are caused by a software glitch.
The S22 Ultra does NOT come with replacement Tips or the tool to remove existing tip, unless the S-Pen was purchased as a replacement, which the OP never implies.
There is a way to get the phone to pair to the s pen, and this may need to be done. Go to:
Settings | Advanced features | S Pen | Air actions | 3 dot menu (upper right corner) | Reset S Pen
For this to work, the S Pen needs to be inserted before you tap Reset S Pen, and can take a few minutes to complete. This is also what you would have to do if you replace your S Pen with a new one.